This project aims to develop a novel acoustic drug delivery (ADD) technique to improve the efficiency of drug delivery to paranasal sinuses significantly. Our pilot studies show that applying a tailored acoustic wave to the nebulised medication (droplets) entering the nostril can enhance the penetration of droplets into sinuses > 45-fold when compared to the nebulisation drug delivery technique (without acoustics). This technique has the potential to improve the sinus drug delivery > 1000-fold when compared to the current gold standard squeeze bottle wash. Anticipated outcome: a cutting-edge compact acoustically-enhanced nebuliser (AEN) to be used in clinical trials for the management of chronic rhinosinusitis (CRS), which has a prevalence ranging from 4.9% to 10.9% worldwide and affects approximately 1.8 million (9.2%) Australians.