Bacteria in biofilms are shielded by a protective layer around each cell, like mortar around bricks. This protects them from antibiotics, making effective treatment difficult Nonetheless, antibiotics are prescribed widely for a miserable condition called chronic rhinosinusitis with sufferers feeling as if they have a permanent head cold. Some patients have bacterial biofilms within the sinuses causing persistent infection and inflammation even after repeated courses of antibiotics and/or sinus surgery, increasing the risk of antibiotic resistance. Infections caused by multi-drug resistant microorganisms is on the rise and we need to act now to minimize the spread of resistance. This study is an exciting opportunity to test both the efficacy and safety of novel antibiofilm products (without the limitations of antibiotics) developed by commercial entities and university-based research in the treatment of sinusitis.