Academic Surgeon-Scientist Research Scholarship - 2018

Immunofluorescence image demonstrating a typical tertiary lymphoid organ

The host-microbe interface in chronic rhinosinusitis
Dr Sathish Paramasivan

Project Description

Bacterial communities have been shown to influence the human body in significant ways. Little research exists, however, on how these bacteria might change the immune system within the nose and sinuses of humans to either contribute towards or prevent the maintenance of healthy nose and sinus function. We aim to investigate the effects that bacteria have on the immune system of the sinuses and whether or not this can contribute to sinus diseases. Our research aims to reveal mechanistic relationships between the immune system and bacteria within the sinus and thereby identify potential targets for treatment of sinus disease.

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